For a recent project, Altran, a leading global engineering consultant company, designed a fluidic circuit for a hemodialysis system. One of the main requirements for hemodialysis is to keep the temperature of the dialysis solution stable while it is flowing through the device. To achieve this, they investigated different layouts and optimal parameters for the fluidic system to minimize heat loss. Since the Finite Element model comprised of more than 7 million elements, they decided to explore different, more rapid simulation strategies for the design exploration stage. Reduced Order Models (ROM) were created using Altair Activate® and Compose® and were validated through comparison with existing CFD models. The use of ROMs, with 30x shorter simulation time, was not just ideal for quick optimization of the system, but also allowed Altran Engineers to challenge, and significantly alter the existing design of the circuit by increasing the number of considered layouts by 1000% (from 5 to 55).